Formulation and Evaluation of Gastroretentive Floating Drug Delivery System of Atenolol

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Development and Evaluation of Gastroretentive Floating Drug Delivery System of Atenolol

Atenolol, an antihypertensive drug, has poor bioavailability (40-50%) and has has low elimination half life(6 hr). Atenolol is mainly absorbed in the stomach. The floating tablets of atenolol were prepared to increase the gastric retention, extend the drug release and to improve the bioavailability of the drug. The floating tablets were formulated using HPMC 100 cps, sodium alginate, carbopol 9...

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Formulation and evaluation of multiple tablets as a biphasic gastroretentive floating drug delivery system for fenoverine.

A biphasic gastroretentive drug delivery system of fenoverine was developed to maintain constant plasma concentration. The delivery system consisted of a loading-dose tablet and a floating multiple matrix tablet prepared by the direct compression process. The drug release from biphasic GRDDS in 0.1 mol L(-1) HCl and SGF (enzyme free) was sustained over 12 h with buoyant properties. Stability st...

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Formulation and Evaluation of Floating Drug Delivery System of Famotidine

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A multiple-unit floating drug delivery system based on gas formation technique was developed, in order to prolong the gastric residence time and to increase the overall bioavailability of the dosage form. The floating bead formulations were prepared by dispersing nevirapine together with calcium carbonate in a mixture of sodium alginate and hydroxypropyl methylcellulose solution and then drippi...

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ژورنال

عنوان ژورنال: International Journal of Pharma Research and Health Sciences

سال: 2016

ISSN: 2348-6465

DOI: 10.21276/ijprhs.2016.05.06